The Bioinformatics Analysis of Hepatitis C Virus E2 Protein
نویسندگان
چکیده
By the methods of bioinformatics, the sequences of HCV E2 protein from all the genotypes are studied on the variation and the B-cell epitopes. We find that even in the HVR1 and HVR2 regions, there are also some conservative sites, such as T2, G6, G23, and Q26, all of which belong to polar R-base amino acids without charge, and can lost proton to conform hydrogen bond. Meanwhile, we find the conservative amino acids locate on the surface of E2 protein, make up of β-turn and B-cell epitopes. This will contribute to prompt the development of HCV vaccine.
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